Infertility Treatments

Assisted Hatching

In IVF applications, the process of thinning or completely puncturing the outer membrane around the embryo before embryo transfer is called Assisted Hatching. In this article, you can learn the details of the Assisted Hatching process.

Why is Assisted Hatching Needed?

There is a protective membrane around the ovule and the embryo formed after the fertilization stage. This membrane is called the zona pellucida.

This membrane has many important functions. The most important are:

It plays a role in the fertilization of the ovule and in the nutrition and development of the embryo.
Prevents polyspermia, that is after the ovule is fertilized with a sperm, this membrane prevents other sperms from entering the egg.
It protects the embryo and ensures its integrity.

The membrane around the transferred embryos spontaneously cracks or perforates when it reaches the blastocyst stage. This is called hatching. With the perforation of the membrane, the blastocyst comes out of the membrane and comes into direct contact with the endometrium tissue and the adhesion process takes place. In some cases, it is thought that this event becomes difficult or cannot be realized. With the assisted hatching process, the membrane around the embryo is thinned and the process is facilitated.

To Whom Is Assisted Hatching Performed?

If there is recurrent IVF failure
If the age of the woman is over 35
Before frozen embryo transfer
In the presence of thick zona pellucida
Abnormal zona pellucida. Especially in oval-shaped oocytes and embryos, the zona pellucida may be completely or partially double-layered.
Dark cytoplasm
In case of extensive cytoplasmic fragmentation, assisted hatching must be performed.

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